Tshimologong Precinct, Wits University, and the Sita Air Transport Community Foundation are offering a prize of $10 000.
The number of active hubs across Africa has grown by over 50% since 2016, with dozens more expected to launch this year, says GSMA.
The funding will be used to boost the company's innovation capabilities and accelerate global expansion.
Its Everywhere Initiative offers start-ups the chance to win up to $50 000.
ITWeb TV: Does SA have what it takes to produce a billion-dollar unicorn? | Episode #98
Innovation Hub CEO Bangani Mpangalasane discusses Gauteng's budding start-up ecosystem, why SA has yet to produce a unicorn company, and innovation that can be a catalyst for economic development and resolve societal challenges.
The significant rise in availability of fibre has seen adoption increase to 23%, as more local SMEs migrate from ADSL to fibre Internet connectivity.
The Global Entrepreneurship Network has launched a local version of its start-up programme, which is designed to educate entrepreneurs, and connect them with global experts.
This will enable Mastercard to leverage Oltio's infrastructure to enhance its existing suite of digital solutions.
Initial coin offerings took off last year, raising a total of $4.6bn globally, says a PwC report.
The group will bring at least one Ericsson Garage innovation hub to Africa this year, says Ericsson's head of Middle East and Africa.
The MTN SA Foundation wants 20 Gauteng-based SMEs for its 2018 Accelerated Business Development Programme.
These will help the youth organisation guide and implement innovation and skills development programmes throughout SA.